Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine
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چکیده
منابع مشابه
Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine.
The ryanodine receptor (RyR) family of proteins constitutes a unique type of calcium channel that mediates Ca(2+) release from endoplasmic reticulum/sarcoplasmic reticulum stores. Ryanodine has been widely used to identify contributions made by the RyR to signaling in both muscle and nonmuscle cells. Ryanodine, through binding to high- and low-affinity sites, has been suggested to block the cha...
متن کاملRyanodine Receptor
1.1 Size and Evolution The ryanodine receptor (RyR) is a selective Ca release channel that is localized to the endoplasmic reticulum (ER) in both excitable and non-excitable cells. The RyR owes its name to the plant alkaloid and high affinity ligand ryanodine. The functional RyR exists as a tetramer composed of a single unit of approximately 565kDa. To date, it is the largest known ion channel....
متن کاملRyanodine receptor type 3: why another ryanodine receptor isoform?
The family of ryanodine receptor (RyR) genes encodes three highly related Ca2+ release channels: RyR1, RyR2 and RyR3. Until about 10 years ago, RyRs were essentially known only for being the Ca2+ release channels of the sarcoplasmic reticulum of striated muscles, because of the high levels of expression of the RyR1 and RyR2 isoforms in skeletal and cardiac muscles, respectively. In contrast wit...
متن کاملRyanodine receptor interaction with the SNARE-associated protein snapin.
The ryanodine receptor (RyR) is a widely expressed intracellular calcium (Ca(2+))-release channel regulating processes such as muscle contraction and neurotransmission. Snapin, a ubiquitously expressed SNARE-associated protein, has been implicated in neurotransmission. Here, we report the identification of snapin as a novel RyR2-interacting protein. Snapin binds to a 170-residue predicted ryano...
متن کاملRyanodine Receptor Adaptation
signal activates specialized Ca 2 1 release channels, the ryanodine receptors (RyRs), in the sarcoplasmic reticulum (SR). This process is called Ca 2 1 -induced Ca 2 1 release (CICR). Intuitively, the CICR process should be self-regenerating because the Ca 2 1 released from the SR should feedback and activate further SR Ca 2 1 release. However, the CICR process is precisely controlled in the he...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.041608898